The Portal Project invites pharmaceutical companies to join.

There are several ways to participate in the Portal, but we welcome other ideas and options.

1. Provide information about compounds that are available for academic repositioning studies. If you are unable to release such information, we suggest an indirect way of communication. An academic researcher fills out the request form based on desired mechanism of action for a compound they always wanted to have but did not know existed (Dream Compounds).

2. Provide off-patent compounds that are no longer of strategic value, for the Portal-CWHM venture.

3. Prepare a Request for Proposal for a particular compound: does anyone have any idea what else this compound may be used for?

4. Sponsor development of the Foci-of-Expertise, a database and visualization tool for finding potential collaborators for drug repositioning or other collaborative opportunities.

 

About the Portal

Drug repositioning is a recent effort in the pharmaceutical industry. It aims to find new uses for the marketed or pipeline drugs, typically by identifying a new disease indication, new delivery method or new combination with other drugs. Only about 11,000 compounds reached Phase II and III clinical trials. Only 2,800 compounds were approved by the FDA over the past 60 years. Thus, these 13,800 compounds represent the most desirable targets for drug repositioning.

The academic research often finds novel targets, but a few academic researchers have an ability to develop drugs for these targets in the academic setting. Therefore, a drug with an established clinical safety profile presents an attractive opportunity for translational research, satisfying both academic and commercial goals. The marriage of the two would undoubtedly result in an increased number of approved drugs for new indications, and thus in considerable public benefit.

The Pharmaceutical Assets Portal project aims to facilitate the match between CTSA-affiliated investigators and the pharmaceutical industry with the aim of developing research partnerships based on compounds shelved at the clinical stage.

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